- using R version 4.4.2 (2024-10-31)
- using platform: x86_64-pc-linux-gnu
- R was compiled by
gcc-14 (Debian 14.2.0-6) 14.2.0
GNU Fortran (Debian 14.2.0-6) 14.2.0
- running under: Debian GNU/Linux trixie/sid
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- checking for file ‘tsdf/DESCRIPTION’ ... OK
- checking extension type ... Package
- this is package ‘tsdf’ version ‘1.1-8’
- package encoding: UTF-8
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See the install log for details.
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checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
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checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:38: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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- DONE
Status: 2 NOTEs